Sloss performed his first live comedy "open spot" at The Laughing Horse in Edinburgh, August 2007, after completing their two day stand-up comedy course. His set was five minutes long.
His first Edinburgh Festival Fringe was in August 2008 where he shared a 30 minute show with fellow comic Davey See, "Life in 2D" in the Espionage venue as part of the Laughing Horse's Free Festival. That same Fringe, aged just 17, Daniel became one of the youngest-ever finalists in the UK's premier So You Think You're Funny? comedy competition. In 2009, he sold out his debut full length Edinburgh Festival Fringe season "Daniel Sloss – Teenage Kicks" and in October took this show to London to the Soho Theatre to become the youngest comedian to perform a solo season in the venue as well as in London's West End.
In April 2010 Daniel made his Australian debut, appearing on Australia's top-rating TV panel show Good News Week, and performing a series of club shows as well as premiering his solo show as part of the Sydney Comedy Festival.
In August 2010, Daniel's second solo show "Daniel Sloss – My Generation" sold out the entire run at The Pleasance venue at Edinburgh Festival Fringe. The show later transferred to London for a season at the Soho Theatre in September and then, due to demand, it returned to London during the tour playing at the Bloomsbury Theatre in November.
In 2011, Daniel made a sell-out return to the Sydney Comedy Festival and then embarked on a tour across South East Asia with fellow comic Craig Hill. He also signed one of the biggest ever UK DVD deals for a comedian, let alone a new-comer, with BBC Worldwide’s prestigious distribution company 2Entertain. His debut DVD "Daniel Sloss - Live".
In August 2011, Daniel premiered his new show "Daniel Sloss - The Joker" at the Edinburgh Fringe, becoming one of the biggest ticket sellers across the fringe selling out every seat to every show for his nearly 4 week run in the flagship new 400 seat Assembly Theatre venue, still aged just 20. This was followed by a Live Nation-produced 50 date national tour.
In July 2012 he was one of the very few comedians invited to perform a solo season at Montreal's prestigious Just For Laughs comedy festival. His week of shows in the plus his television spot on BBC America's Festival showcase Funny as Hell were extremely well received and he was hailed as a great success.
2013 kicked off with sell-out tours of Norway and Sweden as well as performances at the Altitude Comedy Festival in the in Austrian alps alongside John Bishop and Eddie Izzard, from which Daniel was featured in ITV2s documentary about the event. He also returned to Australia for seasons at the Sydney International Comedy Festival and Perth International Comedy Festival.
In August 2013 he launches his new show "DANIEL SLOSS – STAND-UP" at the Edinburgh fringe, again with an extended season at the Edinburgh Conference Centre, with this show touring into the Autumn/Winter of 2013.